The in Vitro Effects of The Antimalarial Drug Primaquine, on The Activities of Some Enzymes in Human Erythrocyte Lyzates
نویسندگان
چکیده
Among the enzymes studied glucose-6phosphate dehydrogenase seemed the most sensitive enzyme; 57 % and 78 % inhibition at zero (due to the binding of primaquine to NADP binding site) and 30 minutes of incubation (due to the reactive oxygen species), respectively. Catalase, superoxide dismutase, and glutathione-S-transferase were less sensitive to primaquine-derived reactive oxygen species: 33, 11, and 0 % inhibition at the time zero and 39, 27, and 4 %, at the end of 30 minutes of incubation. Glutathione reductase and glutathione peroxidase were resistant to primaquinederived reactive oxygen species.
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